50-41-9 MSDS - Clomifene citrate
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Clomifene citrate

Identification
Name Clomifene citrate
CAS Registry Number 50-41-9
Synonyms SEROPHENE;PERGOTIME;CLOMPHID;CLOMID;CLOMIFENE CITRATE;CLOMIPHENE CITRATE;CLOMIPHENE CITRATE SALT;2-[4-(2-CHLORO-1,2-DIPHENYLETHENYL)-PHENOXY]-N,N-DIETHYLETHANAMINE CITRATE SALT
Molecular Structure Clomifene citrate   50-41-9
Molecular Formula C32H36ClNO8
Molecular Weight 598.08
mp: 116.5-118℃
Hazard Codes: Details
Risk Statements: 60-63
Safety Statements: 53-36/37-45
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
50-41-9.pdf
Clomifene
Clomifene.svg
Clomifene ball-and-stick.png
Clinical data
Trade names Clomid, others[1]
AHFS/Drugs.com Monograph
Pregnancy
category
  • AU: B3
  • US: X (Contraindicated)
Routes of
administration
by mouth
ATC code
  • G03GB02 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability High (>90%)
Metabolism liver (with enterohepatic circulation)
Biological half-life 5-7 days
Excretion mainly kidney, some biliary
Identifiers
CAS Number
  • 911-45-5 YesY
PubChem CID
  • 2800
IUPHAR/BPS
  • 4159
DrugBank
  • DB00882 YesY
ChemSpider
  • 2698 YesY
UNII
  • 1HRS458QU2
KEGG
  • D07726 YesY
ChEBI
  • CHEBI:3752 YesY
ChEMBL
  • CHEMBL1200667 N
ECHA InfoCard 100.011.826
Chemical and physical data
Formula C26H28ClNO
Molar mass 406 or 598.10 g/mol (with citrate)
3D model (Jmol)
  • Interactive image
 NYesY (what is this?)  (verify)

Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate. This includes those who have polycystic ovary syndrome. Use results in a greater chance of twins. It is taken by mouth once a day.[2]

Common side effects include pelvic pain and hot flushes.[2] Other side effects can include changes in vision, vomiting, trouble sleeping, ovarian cancer, and seizures.[3][2] It is not recommended in people with liver disease or who are pregnant.[3] Clomifene is in the selective estrogen receptor modulator (SERM) family of medication.[4] It works by causing the release of gonadotrophin by the hypothalamus.[3]

Clomifene was approved for medical use in the United States in 1967.[2] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] It is available as a generic medication.[2] The wholesale cost in the developing world is about 0.79 to 2.00 USD for a course of treatment.[6] In the United States the wholesale cost of a course of treatment is 4.80 USD.[7] Its introduction began the era of assisted reproductive technology.[8]


 







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